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Faulty gene identified in percentage of pancreatic cancers

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According to research published in the esteemed journal Nature, a new class of drug may be able to help treat a minority of patients with aggressive pancreatic cancer.

The work, carried out by Cancer Research UK's Cambridge Research Institute and the Wellcome Trust Sanger Institute, demonstrated that a gene known as USP9x switches off thanks to chemical tagging on the surface of DNA in human cancer cells and in mice cancer cells.

This faulty gene is believed to exist in as many as 15 percent of all pancreatic cancer patients, and that it could serve as an effective therapeutic target if a medication can be developed that can take away the chemical tagging responsible for switching the gene off.

The gene, USP9x, is not normally identified when discussing genes involved in cancer because it it not found when scientists look for DNA sequence changes.

Patients with pancreatic cancer are desperate for such a treatment. As things are, most patients don't survive twelve months following their diagnosis, and those that do make it that long, tend not to make it much longer.

Source: Nature

 

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